|
KMID : 1161420230260010036
|
|
Journal of Medicinal Food
2023 Volume.26 No. 1 p.36 ~ p.39
|
|
|
Evidence of the Cardioprotective Effects of Aloysia polystachya in Isoproterenol-Induced Myocardial Infarction in Rats
|
|
Karyne Garcia Tafarelo Moreno
Thiago Lima de Almeida
Aline Aparecida Macedo Marques
Guilherme Donadel
Emerson Luiz Botelho Lourenco
Rebecca Schembri-Higgans
Chung Jong-Hoon
|
|
|
Abstract
|
|
|
|
Aloysia polystachya is a plant species that is widely used in Brazilian folk medicine for the treatment of different disorders that affect the cardiovascular system. The aim of the study was to investigate the cardioprotective effects of an ethanol-soluble fraction of A. polystachya (ESAP) on isoproterenol-induced myocardial infarction in rats. Different groups of rats (n?=?8) were orally treated with ESAP (30, 100, and 300?mg/kg), carvedilol (10?mg/kg), or vehicle (filtered water; 1?mL/100?g) for 7 days. Naive rats received no treatment. On the morning of day 6, acute myocardial infarction was induced by the acute oral administration of isoproterenol (100?mg/kg). On the morning of day 8, all rats underwent electrocardiography and transthoracic echocardiography. Blood samples were then collected, and serum levels of creatine kinase-MB fraction (CK-MB) and cardiac troponin T (cTNT) were quantified. ESAP significantly reduced electrocardiographic changes, improved the ventricular ejection fraction, and reduced serum levels of CK-MB and cTNT in infarcted rats. The cardioprotective effects of ESAP could be exploited as an effective tool against isoproterenol-induced myocardial infarction in rats.
|
|
|
KEYWORD
|
|
|
creatine kinase, heart attack, troponin, Verbenaceae
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|